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Monogenic and Polygenic Risk for Kidney Cancer in Two Large Biobanks.

European urology oncology - 1 Jun 2026

Wei Jun, Mulford Ashley J, Shi Zhuqing, Tran Huy, Ashworth Annabelle, Zheng S Lilly, Lu Jim, Sanders Alan R, Bhanvadia Raj, Novakovic Kristian, Tobert Conrad, Helfand Brian, Singla Nirmish, Lane Brian, Xu Jianfeng

Abstract excerpt

BACKGROUND: Pathogenic variants (PVs) in monogenic genes and polygenic risk scores (PRS) have been associated with kidney cancer risk. However, their joint contributions in the general population remain unclear. DESIGN, SETTING, AND PARTICIPANTS: Associations of kidney cancer with PVs in 15 core renal cell carcinoma (RCC) hereditary genes and 22 other cancer-susceptibility genes, and a published PRS (PGS004908)...

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PMID: 41864770
DOI: 10.1016/j.euo.2026.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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