Article
Active DNA end processing in micronuclei of ovarian cancer cells.
BMC cancer - 16 Apr 2018
Tang Zizhi, Yang Juan, Wang Xin, Zeng Ming, Wang Jing, Wang Ao, Zhao Mingcai, Guo Liandi, Liu Cong, Li Dehua, Chen Jie
Abstract excerpt
BACKGROUND: Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with genomic instability caused by defined sets of pathogenic mutations. In contrast, the mechanism that influences the development of drug resistance and disease recurrence is not...
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