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Article

Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration

2023-10-03

Abstract excerpt

<h4>Summary</h4> Parkinson’s disease (PD) targets some dopamine (DA) neurons more than others. Sex differences offer insights, with females more protected from DA neurodegeneration. The mammalian vesicular glutamate transporter VGLUT2 and Drosophila ortholog dVGLUT have been implicated as modulators of DA neuron resilience. However, the mechanisms by which VGLUT2/dVGLUT protects DA neurons remain unknown. We dis...

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Literature Corpus work
055eb890-6e28-5b43-a41d-bee496179fc3
DOI
10.1101/2023.10.02.560584
Open publication

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Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegenerationDOI 10.1101/2023.10.02.560584
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