Article

Sex-Dependent Effects of Glutamatergic Disruption on Dopaminergic Neuron Subtype Vulnerable in Parkinson’s Disease

2026-05-11

Abstract excerpt

Aldehyde dehydrogenase 1A1-positive (ALDH1A1 + ) dopaminergic neurons (DANs) are preferentially vulnerable in Parkinson’s disease (PD), yet how their activity is modulated by presynaptic inputs remains poorly defined. Here we investigated the role of glutamatergic input by conditionally deleting Grin1 , which encodes a critical NMDA receptor (NMDAR) subunit, in ALDH1A1 + DANs. Grin1 conditional knockout (cKO)...

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Literature Corpus work: 1d76cec2-2128-5df3-8a3e-46a0e534a59d
DOI: 10.64898/2026.05.06.723291

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