Article

Gasdermin E couples mitochondrial damage to pyroptotic neurodegeneration in Parkinson’s disease

2025-12-16

Abstract excerpt

Parkinson’s disease (PD) features progressive loss of nigrostriatal dopamine neurons, but how mitochondrial damage engages programmed cell death pathways remains unresolved. Here, we identify gasdermin E (GSDME), the caspase-3-activated executor of pyroptosis, as a critical mediator of neurodegeneration in toxin-based PD models. In primary neurons and SH-SY5Y cells, the mitochondrial complex I inhibitor MPTP/MPP⁺...

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Identifiers and source

Literature Corpus work: 31649f11-9fa8-573b-a64d-a7a13ec48bea
DOI: 10.64898/2025.12.14.694264

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