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Article

SARS-CoV-2 infection causes dopaminergic neuron senescence

17 Jan 2024

Abstract excerpt

COVID-19 patients commonly present with signs of central nervous system and/or peripheral nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection of DA neurons triggers an inflammatory and cellular...

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PMID: 38237586
DOI: 10.1016/j.stem.2023.12.012

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