Article

Products of the Parkinson’s-disease related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

2014-07-04

Abstract excerpt

Parkinson’s disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra . One of the genes, DJ-1/PARK7, linked with the onset of Parkinson’s disease, belongs to a novel glyoxalase family and influences mitochondrial activity. It has been assumed that glyoxalases fulfill this task by detoxifying aggressive aldehyde by-products of metabolism. Here we show that supplying either D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc1269c5-fa69-5f4c-882f-c8f309fdf2be
DOI: 10.1101/006916

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Products of the Parkinson’s-disease related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survivalDOI 10.1101/006916Read

DJ-1 products glycolic acid and D-lactate restore deficient axonal trafficking and DNA damage response in FUS and SOD1-associated amyotrophic lateral sclerosisSemantic proximity Read

A conserved role of Parkinson-associated DJ-1 metabolites in sperm motility, mitosis, and embryonic developmentSemantic proximity Read

Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.Semantic proximity Read

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal DetoxificationSemantic proximity Read

DJ-1 mediates regulation of metabolism and immune response in Parkinson’s disease astrocytes and Glioblastoma cellsSemantic proximity Read

Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson’s disease based on DJ-1 deficiencySemantic proximity Read

The combination of glycolic acid and D-lactate delays disease progression in SOD-1 ALS mice, partially rescues lethality in iTBPH pkk(108354) Drosophila and shows promising results in experimental treatments in two ALS patientsSemantic proximity Read

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neuronsSemantic proximity Read

Human DJ-1 and its homologs are novel glyoxalasesSemantic proximity Read

Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegenerationSemantic proximity Read

Antioxidants put Parkinson flies back in the PINK.Semantic proximity Read

Modulatory roles of glycolytic enzymes in cell deathSemantic proximity Read