Article

Genetically encoded nAChR upregulation is neuroprotective in female parkinsonian mice

2025-06-25

Abstract excerpt

Parkinson’s disease is projected to rise to pandemic proportions by 2050, which has resulted in an urgent need for disease-modifying treatments. In this regard, we previously showed that in a mouse model of parkinsonism with unilateral 6-hydroxydopamine (6-OHDA) injection into the dorsolateral striatum (DLS), low doses of the neuronal nicotinic acetylcholine receptor (nAChR) partial agonist and smoking cessation d...

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Literature Corpus work: 18c8ba60-6bba-5fce-a8fc-3757498b4d22
DOI: 10.1101/2025.06.23.661175

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