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Article

Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration.

Neurobiology of disease - 1 Feb 2011

Daniels Richard W, Miller Bradley R, DiAntonio Aaron

Abstract excerpt

Increases in vesicular glutamate transporter (VGLUT) levels are observed after a variety of insults including hypoxic injury, stress, methamphetamine treatment, and in genetic seizure models. Such overexpression can cause an increase in the amount of glutamate released from each vesicle, but it is unknown whether this is sufficient to induce excitotoxic neurodegeneration. Here we show that overexpression of the...

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Identifiers

PMID: 20951206
DOI: 10.1016/j.nbd.2010.10.009
PMCID: PMC3014407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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