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Article

Impaired NADH-linked mitochondrial respiration disrupts ventral midbrain neuronal programs in POLG disease.

Journal of translational medicine - 31 Jul 2026

Chen Anbin, Yangzom Tsering, Sullivan Gareth John, Liang Kristina Xiao

Abstract excerpt

BACKGROUND: POLG (DNA polymerase γ catalytic subunit)-related mitochondrial diseases are among the most severe primary mitochondrial disorders and are characterized by progressive neurodegeneration with prominent dopaminergic involvement. However, the cell type-specific mechanisms linking mitochondrial DNA instability to neuronal vulnerability remain incompletely defined. METHODS: Using patient-derived midbrain...

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Identifiers

PMID: 42552539
DOI: 10.1186/s12967-026-08706-w
PMCID: PMC13435581

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Impaired NADH-linked mitochondrial respiration disrupts ventral midbrain neuronal programs in POLG disease.PMID 42552539Read ↗

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