Article

Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies <i>in vivo</i>

2025-08-30

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) show promise for HIV treatment and prevention, but are vulnerable to resistance evolution. Comprehensively understanding in vivo viral escape from individual bNAbs is necessary to design bNAb combinations that will provide durable responses. We characterize viral escape from two such bNAbs, 10-1074 and 3BNC117, using deep, longitudinal sequencing of full length HIV envelope...

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Literature Corpus work: 0553779a-5a29-5adb-8d01-c4c53db0ce75
DOI: 10.1101/2025.08.29.673185

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