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Article

Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope.

Journal of virology - 15 Sept 2017

Anthony Colin, York Talita, Bekker Valerie, Matten David, Selhorst Philippe, Ferreria Roux-Cil, Garrett Nigel J, Karim Salim S Abdool, Morris Lynn, Wood Natasha T, Moore Penny L, Williamson Carolyn

Abstract excerpt

V3-glycan-targeting broadly neutralizing antibodies (bNAbs) are a focus of HIV-1 vaccine development. Understanding the viral dynamics that stimulate the development of these antibodies can provide insights for immunogen design. We used a deep-sequencing approach, together with neutralization phenotyping, to investigate the rate and complexity of escape from V3-glycan-directed bNAbs compared to overlapping early...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28679760
DOI: 10.1128/JVI.00828-17
PMCID: PMC5571269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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