Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies.

PLoS pathogens - 1 Aug 2018

Otsuka Yuka, Schmitt Kimberly, Quinlan Brian D, Gardner Matthew R, Alfant Barnett, Reich Adrian, Farzan Michael, Choe Hyeryun

Abstract excerpt

Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapid emergence of resistant viruses. Here we show that soft-randomization can be used to accelerate the parallel identification of viral escape pathways. As a proof of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epitopes
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Neutralizing

Share to Broadly Neutralizing Antibodies

Share to HEK293 Cells

Share to HIV Antibodies

Share to Immune Evasion

Share to Neutralization Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 30125330
DOI: 10.1371/journal.ppat.1007238
PMCID: PMC6117093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies.PMID 30125330Read ↗

Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1Semantic proximity Read ↗

Diverse paths to broadly neutralizing antibody escape among HIV-1 strains.Semantic proximity Read ↗

Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies <i>in vivo</i>Semantic proximity Read ↗

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV vectored immunotherapy in humanized miceSemantic proximity Read ↗

Comprehensive maps of escape mutations from antibodies 10-1074 and 3BNC117 for Envs from two divergent HIV strains.Semantic proximity Read ↗

Accurate Prediction for Antibody Resistance of Clinical HIV-1 IsolatesSemantic proximity Read ↗

Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo.Semantic proximity Read ↗

<scp>HIV</scp>‐1 neutralizing antibodies: understanding nature's pathwaysSemantic proximity Read ↗

Comprehensive mapping of the virus and host factors that guide the paths of HIV-1 escape from a therapeutic.Semantic proximity Read ↗

Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance.Semantic proximity Read ↗

Accurate Prediction of Antibody Resistance in Clinical HIV-1 IsolatesSemantic proximity Read ↗

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.