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Article

Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2026

Romero Elena V, Clyde Abigail E, Giorgi Elena E, Westfall Dylan H, Azam Walker, Taylor Megan L, Caskey Marina, Feder Alison F, Cohn Lillian B

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) show promise for HIV treatment and prevention, but are vulnerable to resistance evolution. Comprehensively understanding in vivo viral escape from individual bNAbs is necessary to design bNAb combinations that will provide durable responses. We characterize viral escape from two such bNAbs, 10-1074 and 3BNC117, using deep, longitudinal sequencing of full-length HIV envelope...

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Topics

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Share to Antibodies, Neutralizing
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to HIV Antibodies

Share to HIV Infections

Share to Immune Evasion

Share to Mutation

Source

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Identifiers

PMID: 41980093
DOI: 10.1073/pnas.2524021123
PMCID: PMC13099683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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