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Article

Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus.

Journal of virology - 1 Dec 2012

Sather D Noah, Carbonetti Sara, Kehayia Jenny, Kraft Zane, Mikell Iliyana, Scheid Johannes F, Klein Florian, Stamatatos Leonidas

Abstract excerpt

Approximately 1% of those infected with HIV-1 develop broad and potent serum cross-neutralizing antibody activities. It is unknown whether or not the development of such immune responses affects the replication of the contemporaneous autologous virus. Here, we defined a pathway of autologous viral escape from contemporaneous potent and broad serum neutralizing antibodies developed by an elite HIV-1-positive...

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Share to Antibodies, Neutralizing
Share to Antibody Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites, Antibody

Share to CD4 Antigens

Share to Enzyme-Linked Immunosorbent Assay

Share to HIV Envelope Protein gp160

Share to Neutralization Tests

Share to Virus Internalization

Source

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Identifiers

PMID: 22973035
DOI: 10.1128/JVI.01893-12
PMCID: PMC3497623

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