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Article

Diverse paths to broadly neutralizing antibody escape among HIV-1 strains.

Nature microbiology - 1 Jun 2026

Stabell Alex C, Lee Songhee, Park Debby J, Lavine Christy L, Espinosa Sebastian Mejia, Baharani Viren A, Patejak Rachel, Nussenzweig Michel C, Caskey Marina, Seaman Michael S, Bieniasz Paul D, Hatziioannou Theodora

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) are promising agents for HIV-1 treatment and prevention. However, the genetic barriers and mutational pathways to viral resistance, which can limit therapeutic antibody utility, remain poorly defined. Here we developed a medium-to-high throughput approach to determine the mutations that confer resistance to neutralization by the bnAbs 3BNC117 and 10-1074 currently in...

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Share to Antibodies, Monoclonal, Humanized
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Viral

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Share to HIV Infections

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Source

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Identifiers

PMID: 42115740
DOI: 10.1038/s41564-026-02347-x
PMCID: PMC13236584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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