Article

Generation and validation of an aryl hydrocarbon receptor knockout human embryonic stem cell line

2025-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Glucose homeostasis is tightly controlled by hormones secreted from pancreatic islets. The most abundant cell type in islets is the β-cell, which secretes insulin in response to nutritional stimuli. We previously reported that the adverse metabolic effects of high-dose dioxin exposure in mice are regulated by the aryl hydrocarbon receptor (AHR) specifically in β-cells. Additionally, fetal exposu...

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Literature Corpus work: 05045f37-0667-5ca9-84f4-2afc8fa19983
DOI: 10.1101/2025.10.29.685330

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