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Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences

11 Dec 2018

Abstract excerpt

Fluorescent protein reporter genes are widely used to identify and sort murine pancreatic β-cells. In this study, we compared use of the MIP-GFP transgene, which exhibits aberrant expression of human growth hormone (hGH), with a newly derived Ins2Apple allele that lacks hGH expression on the expression of sex-specific genes. β-Cells from MIP-GFP transgenic mice exhibit changes in the expression of 7,733 genes, or...

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PMID: 30532991
DOI: 10.1152/ajpendo.00229.2018

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