Article

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

2022-06-05

Abstract excerpt

<h4>Aims/hypothesis</h4> Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycemic traits. However, little is known about the function of the zinc finger transcription factor RREB1 in glucose homeostasis or how changes in its expression and/or function influence diabetes risk. <h4>Methods</h4> A zebrafish model lacking...

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Literature Corpus work: fd36f675-9e4d-50c9-b74a-8d02bc789175
DOI: 10.1101/2022.06.04.494826

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