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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

12 Jan 2023

Abstract excerpt

Abstract Aims/hypothesis Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. However, little is known about the function of the zinc finger transcription factor Ras-responsive element binding protein 1 (RREB1) in glucose homeostasis or how changes in its expression and/or function influence diabetes risk....

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PMID: 36633628
DOI: 10.1007/s00125-022-05856-6

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