Article

Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells

2023-05-08

Abstract excerpt

<h4>Summary</h4> Genetic studies have identified numerous loci associated with type 2 diabetes (T2D), but the functional role of many loci has remained unexplored. In this study, we engineered isogenic knockout human embryonic stem cell (hESC) lines for 20 genes associated with T2D risk. We systematically examined β-cell differentiation, insulin production and secretion, and survival. We performed RNA-seq and ATA...

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Literature Corpus work: 7e082a97-ad5c-551d-9ec9-18553f516fb3
DOI: 10.1101/2023.05.07.539774

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