Article

Crosstalk between the aryl hydrocarbon receptor and hypoxia inducible factor 1α pathways impairs downstream dioxin response in human islet models

2024-09-26

Abstract excerpt

The incidence of type 2 diabetes (T2D) is increasing globally at a rate that cannot be explained solely by genetic predisposition, diet, or lifestyle. Epidemiology studies report positive associations between exposure to persistent organic pollutants, such as dioxins, and T2D. We previously showed that 2,3,7,8 tetrachlorodibenzo- p -dioxin (TCDD) activates the xenobiotic-sensitive aryl hydrocarbon receptor (AHR)...

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Literature Corpus work: 6aae5e23-bee6-509e-bde2-346de9a5e3c6
DOI: 10.1101/2024.09.25.615065

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