Article

Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms

2023-10-31

Abstract excerpt

Myeloproliferative neoplasms (MPNs) encompass a diverse group of hematologic disorders driven by mutations in JAK2, CALR, or MPL. The prevailing working model explaining how these driver mutations induce different disease phenotypes is based on the decisive influence of the cellular microenvironment and the acquisition of additional mutations. Here, we report increased levels of chromatin segregation errors in hem...

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Literature Corpus work: 04f41c24-d155-55b5-ab05-3a4b9ef1979d
DOI: 10.21203/rs.3.rs-3481654/v1

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