Article
Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2016
Liu Xia, Zheng Hong, Li Xiaobo, Wang Siying, Meyerson Howard J, Yang Wentian, Neel Benjamin G, Qu Cheng-Kui
Abstract excerpt
Gain-of-function (GOF) mutations of protein tyrosine phosphatase nonreceptor type 11 Ptpn11 (Shp2), a protein tyrosine phosphatase implicated in multiple cell signaling pathways, are associated with childhood leukemias and solid tumors. The underlying mechanisms are not fully understood. Here, we report that Ptpn11 GOF mutations disturb mitosis and cytokinesis, causing chromosomal instability and greatly...
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