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Article

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.

Nature - 16 Sept 2010

Liu Han, Takeda Shugaku, Kumar Rakesh, Westergard Todd D, Brown Eric J, Pandita Tej K, Cheng Emily H-Y, Hsieh James J-D

Abstract excerpt

Cell cycle checkpoints are implemented to safeguard the genome, avoiding the accumulation of genetic errors. Checkpoint loss results in genomic instability and contributes to the evolution of cancer. Among G1-, S-, G2- and M-phase checkpoints, genetic studies indicate the role of an intact S-phase checkpoint in maintaining genome integrity. Although the basic framework of the S-phase checkpoint in multicellular...

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Identifiers

PMID: 20818375
DOI: 10.1038/nature09350
PMCID: PMC2940944

Genes

ATR
CDC45

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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