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Article

The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?

26 Nov 2019

Abstract excerpt

Mitosis is the process whereby an eukaryotic cell divides into two identical copies. Different multiprotein complexes are involved in the fine regulation of cell division, including the mitotic promoting factor and the anaphase promoting complex. Prolonged mitosis can result in cellular division, cell death, or mitotic slippage, the latter leading to a new interphase without cellular division. Mitotic slippage is...

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PMID: 31771633
DOI: 10.1186/s13045-019-0808-4

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