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Article

Megakaryocytic hyperplasia in myeloproliferative neoplasms is driven by disordered proliferative, apoptotic and epigenetic mechanisms.

Journal of clinical pathology - 1 Feb 2016

Malherbe Jacques A J, Fuller Kathryn A, Arshad Ayesha, Nangalia Jyoti, Romeo Giuliana, Hall Sara L, Meehan Katie S, Guo Belinda, Howman Rebecca, Erber Wendy N

Abstract excerpt

AIMS: Myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal proliferative bone marrow diseases characterised by extensive megakaryocytic hyperplasia and morphological atypia. Despite knowledge of genomic defects, the pathobiological processes driving these megakaryocytic abnormalities in MPN remain poorly explained. We have explored the proliferative, apoptotic and epigenetic profiles of...

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Source

Identifiers

PMID: 26290261
DOI: 10.1136/jclinpath-2015-203177

Genes

CALR
SUZ12
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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