Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability.

The Journal of biological chemistry - 9 Nov 2012

Krem Maxwell M, Luo Ping, Ing Brandon I, Horwitz Marshall S

Abstract excerpt

The malignant cell in classical Hodgkin lymphoma (HL) is the binucleated giant Reed-Sternberg cell. Chromosomal instability and mitotic errors may contribute to HL pathogenesis; one potential mitotic regulator is the kelch protein KLHDC8B, which localizes to the midbody, is expressed during mitosis, and is mutated in a subset of familial and sporadic HL. We report that disrupting KLHDC8B function in HeLa cells, B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Centrosome
Share to Chromosomal Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokinesis

Share to Hodgkin Disease

Share to Karyotyping

Share to Mitosis

Share to Reed-Sternberg Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 22988245
DOI: 10.1074/jbc.M112.390088
PMCID: PMC3493949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability.PMID 22988245Read ↗

Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma.Semantic proximity Read ↗

Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells.Semantic proximity Read ↗

Chromosomal Instability in Hodgkin Lymphoma: An In-Depth Review and PerspectivesSemantic proximity Read ↗

Characteristics of the Kelch domain containing ( KLHDC ) subfamily and relationships with diseasesSemantic proximity Read ↗

Whole genome doubling confers unique genetic vulnerabilities on tumor cellsSemantic proximity Read ↗

Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome InstabilitySemantic proximity Read ↗

A Prognostic and Immunological Analysis of 7B-containing Kelch structural domain（KLHDC7B）in Pan- Cancer: A Potential Target for Immunotherapy and SurvivalSemantic proximity Read ↗

Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and agingSemantic proximity Read ↗

Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.Semantic proximity Read ↗

An anaphase surveillance mechanism prevents micronuclei formation from mitotic errorsSemantic proximity Read ↗

Kinetochore Malfunction in Human Pathologies.Semantic proximity Read ↗

Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.