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Article

Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms.

Scientific reports - 2 Feb 2024

Holl Kristin, Chatain Nicolas, Krapp Susanne, Baumeister Julian, Maié Tiago, Schmitz Sarah, Scheufen Anja, Brock Nathalie, Koschmieder Steffen, Moreno-Andrés Daniel

Abstract excerpt

Myeloproliferative neoplasms (MPNs) encompass a diverse group of hematologic disorders driven by mutations in JAK2, CALR, or MPL. The prevailing working model explaining how these driver mutations induce different disease phenotypes is based on the decisive influence of the cellular microenvironment and the acquisition of additional mutations. Here, we report increased levels of chromatin segregation errors in...

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Identifiers

PMID: 38308077
DOI: 10.1038/s41598-024-53240-8
PMCID: PMC10837458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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