Article
JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.
Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014
Chen Edwin, Ahn Jong Sook, Massie Charlie E, Clynes David, Godfrey Anna L, Li Juan, Park Hyun Jung, Nangalia Jyoti, Silber Yvonne, Mullally Ann, Gibbons Richard J, Green Anthony R
Abstract excerpt
Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as an early somatic event in most patients with myeloproliferative neoplasms (MPNs), and the study of these chronic myeloid malignancies provides an...
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