Article

Mitotic CDK4/6 activity sustains spindle checkpoint signalling to prevent mitotic slippage and genomic instability

2025-09-15

Abstract excerpt

The precise regulation of cell cycle entry and the maintenance of genome integrity are crucial for preventing tumorigenesis. Cyclin-dependent kinases 4 and 6 (CDK4/6) play pivotal roles in linking mitogenic signals to G1–S phase progression 1–3 , and their frequent deregulation in various cancers underscores their importance in driving cell proliferation and as therapeutic targets 4,5 . Despite this, the roles o...

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Literature Corpus work: a49076dc-bb40-5359-88b1-a048e7653c72
DOI: 10.1101/2025.09.13.675969

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