Article

MTFR2 regulates mitochondrial fission and impacts spindle integrity during mitosis

2020-09-13

Abstract excerpt

Previously we reported that mitochondrial fission regulator 2 (MTFR2, also termed DUFD1 or FAM54A) is co-transcribed with core centromere/kinetochore components, indicating a possible role in mitosis regulation. Here we show that human MTFR2 is a mitochondrial outer membrane protein and participates in DRP1 dependent mitochondrial fission. Multiple MTFR2 variants identified in cancer samples are defective in trig...

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Literature Corpus work: fe9b150d-9fdb-5e1a-8557-45b2bdf458a7
DOI: 10.1101/2020.09.13.293621

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