Article

Polo-like kinase-1 Inhibitors and the Antiandrogen Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

2022-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Abiraterone, a standard treatment for metastatic castrate-resistant prostate cancer (mCRPC), slows disease progression by abrogating androgen synthesis and antagonizing the androgen receptor (AR). We report that inhibitors of the mitotic kinase Plk1, including the clinically active third-generation Plk1 inhibitor onvansertib, when co-administered with abiraterone, synergistically kill cancer cel...

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Literature Corpus work: 0ac352de-c243-5caf-ba6a-8c9a9a4005a3
DOI: 10.1101/2022.05.12.491633

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