Article

The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells

2022-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Clonal hematopoiesis (CH) increases the risk for the development of hematological malignancy and cardiovascular disease. IL1β is elevated in patients with CH and its inhibition mitigates cardiovascular risk in murine models with Tet2 loss-of-function. How IL1β alters population dynamics of hematopoietic cells upon Tet2 deletion ( Tet2 -KO) is not well understood. We demonstrated IL1β expands...

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Literature Corpus work: 04d8378d-e3e4-5f11-8e13-d1170c459172
DOI: 10.1101/2022.09.15.507688

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