Article
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.
Science (New York, N.Y.) - 24 Feb 2017
Fuster José J, MacLauchlan Susan, Zuriaga María A, Polackal Maya N, Ostriker Allison C, Chakraborty Raja, Wu Chia-Ling, Sano Soichi, Muralidharan Sujatha, Rius Cristina, Vuong Jacqueline, Jacob Sophia, Muralidhar Varsha, Robertson Avril A B, Cooper Matthew A, Andrés Vicente, Hirschi Karen K, Martin Kathleen A, Walsh Kenneth
Abstract excerpt
Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. Several of these recurrent mutations, including those in the gene encoding the epigenetic modifier enzyme TET2, promote expansion of the mutant blood cells. This clonal hematopoiesis correlates with an increased risk of atherosclerotic cardiovascular disease. We studied the effects of the expansion of Tet2-mutant...
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