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Article

An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis.

Experimental hematology - 1 Mar 2018

Abegunde Samuel O, Buckstein Rena, Wells Richard A, Rauh Michael J

Abstract excerpt

Clonal hematopoiesis of aging and indeterminate potential (ARCH or CHIP), driven mainly by mutations in DNMT3A and TET2, is an emerging public health issue, affecting at least 10-15% of adults older than 65 years. CHIP is associated with increased risks of de novo and therapy-related hematological neoplasms and serves as a reservoir for leukemic relapse. CHIP is also associated with increased all-cause mortality...

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Source

Identifiers

PMID: 29195897
DOI: 10.1016/j.exphem.2017.11.002

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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