The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.

doi:10.1158/2159-8290.CD-21-1146

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Article

The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.

Cancer discovery - 5 Oct 2022

Yeaton Anna, Cayanan Geraldine, Loghavi Sanam, Dolgalev Igor, Leddin Emmett M, Loo Christian E, Torabifard Hedieh, Nicolet Deedra, Wang Jingjing, Corrigan Kate, Paraskevopoulou Varvara, Starczynowski Daniel T, Wang Eric, Abdel-Wahab Omar, Viny Aaron D, Stone Richard M, Byrd John C, Guryanova Olga A, Kohli Rahul M, Cisneros G Andrés, Tsirigos Aristotelis, Eisfeld Ann-Kathrin, Aifantis Iannis, Guillamot Maria

Abstract excerpt

Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of developing hematopoietic malignancies. Here, we describe a novel animal model carrying a recurrent TET2 missense mutation frequently found in patients with CH and leukemia. In a fashion similar to CH, animals show signs of disease late in...

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Identifiers

PMID: 35924979
DOI: 10.1158/2159-8290.CD-21-1146
PMCID: PMC9547930

Genes

TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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