Article

Development and characterization of a human model of arteriovenous malformation (AVM)-on-a-chip

2022-01-22

Abstract excerpt

Brain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one of the leading causes of hemorrhagic stroke in children and young adults. Most human sporadic brain AVMs are associated with genetic activating mutations in the KRAS gene. Our goal was to develop an in vitro model that would allow...

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Literature Corpus work: 04c52b1f-9798-5a59-95f5-e3156961211e
DOI: 10.1101/2022.01.20.477166

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