MEK signaling represents a viable therapeutic vulnerability of <i>KRAS</i> -driven somatic brain arteriovenous malformations

Abstract excerpt

<h4>ABSTRACT</h4> Brain arteriovenous malformations (bAVMs) are direct connections between arteries and veins that remodel into a complex nidus susceptible to rupture and hemorrhage. Most sporadic bAVMs feature somatic activating mutations within KRAS , and endothelial-specific expression of the constitutively active variant KRAS G12D models sporadic bAVM in mice. By leveraging 3D-based micro-CT imaging, we dem...

Topics

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• Gain of Function Mutation
• Human Umbilical Vein Endothelial Cells
• Intracranial Arteriovenous Malformations
• Intracranial Hemorrhages
• MAP Kinase Kinase 1
• Permeability
• Phosphatidylinositol 3-Kinase
• Phosphoinositide-3 Kinase Inhibitors

Identifiers and source

Literature Corpus work

0832dc3b-5924-5032-8b17-6ac7b78a8e23

DOI

10.1101/2024.05.15.594335