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Article

CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice.

JCI insight - 22 Nov 2024

Saito Shoji, Nakamura Yuka, Miyashita Satoshi, Sato Tokiharu, Hoshina Kana, Okada Masayasu, Hasegawa Hitoshi, Oishi Makoto, Fujii Yukihiko, Körbelin Jakob, Kubota Yoshiaki, Tainaka Kazuki, Natsumeda Manabu, Ueno Masaki

Abstract excerpt

Brain arteriovenous malformations (bAVMs) are anomalies forming vascular tangles connecting the arteries and veins, which cause hemorrhagic stroke in young adults. Current surgical approaches are highly invasive, and alternative therapeutic methods are warranted. Recent genetic studies identified KRAS mutations in endothelial cells of bAVMs; however, the underlying process leading to malformation in the postnatal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39576014
DOI: 10.1172/jci.insight.179729
PMCID: PMC11601911

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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