Article

Endothelial KRAS <sup>G12V</sup> signaling drives aberrant morphogenesis and establishes an AVM transcriptional identity in primary human endothelial cells

2026-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Somatic activating mutations in KRAS are found in the endothelium of the majority of sporadic brain arteriovenous malformations (bAVMs), yet the consequences of oncogenic KRAS signaling in endothelial cells during active vessel morphogenesis remain incompletely characterized. We expressed KRAS G12V in primary human umbilical vein endothelial cells using a doxycycline-inducible lentiviral system...

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Literature Corpus work: d17d86f0-ec1b-5b32-b6b8-487821675cd7
DOI: 10.64898/2026.06.26.734855

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