Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Towards precision medicine for brain arteriovenous malformations.

The Journal of clinical investigation - 15 May 2026

Hale Andrew T, Kundishora Adam J, Kalailingam Pazhanichamy, Barak Tanyeri, Duy Phan Q, Ramundo Christopher M, Fan Baojian, Li Qiang, Brastianos Priscilla K, Shankar Ganesh M, Alper Seth L, Kleinstiver Benjamin P, Musolino Patricia L, Kahle Kristopher T

Abstract excerpt

Recent advances in cerebrovascular genomics, single-cell biology, pharmacology, and gene editing technology are transforming our understanding of brain arteriovenous malformations (bAVMs) - a leading cause of pediatric hemorrhagic stroke. Once considered static anatomical defects, bAVMs are now recognized as dynamic, genetically driven lesions resulting from somatic mutations in KRAS, BRAF, and pathways involved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRAF gene
Share to KRAS gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracranial Arteriovenous Malformations

Share to Mutation

Share to Precision Medicine

Source

Open in PubMed Open full text

Identifiers

PMID: 42138076
DOI: 10.1172/JCI205086
PMCID: PMC13178655

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Towards precision medicine for brain arteriovenous malformations.PMID 42138076Read ↗

Advances in the Genetics and Molecular Biology of Brain Arteriovenous Malformations.Semantic proximity Read ↗

Cerebral vascular malformations: pathogenesis and therapySemantic proximity Read ↗

Arteriovenous Malformations (AVMs): Molecular Pathogenesis, Clinical Features, and Emerging Therapeutic StrategiesSemantic proximity Read ↗

Somatic Mosaicism in the Pathogenesis of de novo Cerebral Arteriovenous Malformations: A Paradigm Shift Implicating the RAS-MAPK Signaling Cascade.Semantic proximity Read ↗

CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice.Semantic proximity Read ↗

Development and characterization of a human model of arteriovenous malformation (AVM)-on-a-chipSemantic proximity Read ↗

Understanding the pathogenesis of brain arteriovenous malformation: genetic variations, epigenetics, signaling pathways, and immune inflammation.Semantic proximity Read ↗

Vascular malformations: An overview of their molecular pathways, detection of mutational profiles and subsequent targets for drug therapySemantic proximity Read ↗

De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous MalformationSemantic proximity Read ↗

Review of treatment and therapeutic targets in brain arteriovenous malformation.Semantic proximity Read ↗

MEK signaling represents a viable therapeutic vulnerability of <i>KRAS</i> -driven somatic brain arteriovenous malformationsSemantic proximity Read ↗

Cerebral Cavernous Malformation: From Mechanism to Therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.