Article
Advances in the Study of KRAS in Brain Arteriovenous Malformation.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2024
Pang Miao, Zhang Guanghao, Shang Chenghao, Zhang Yuhang, Chen Rundong, Li Zhe, Ding Xin, Duan Guoli, Li Qiang
Abstract excerpt
BACKGROUND: Brain arteriovenous malformation (bAVM) is an abnormal vascular mass with disordered arteriovenous connection. Endothelial KRAS mutation is common in bAVM. In vivo studies have demonstrated that mutations of KRAS in somatic cells can induce bAVM-like angiogenesis, suggesting that KRAS gene may play a key role in the development and progression of bAVM. SUMMARY: In this article, we will provide a...
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