Article
Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling.
Circulation research - 28 Aug 2020
Fish Jason E, Flores Suarez Carlos Perfecto, Boudreau Emilie, Herman Alexander M, Gutierrez Manuel Cantu, Gustafson Dakota, DiStefano Peter V, Cui Meng, Chen Zhiqi, De Ruiz Karen Berman, Schexnayder Taylor S, Ward Christopher S, Radovanovic Ivan, Wythe Joshua D
Abstract excerpt
RATIONALE: We previously identified somatic activating mutations in the KRAS (Kirsten rat sarcoma viral oncogene homologue) gene in the endothelium of the majority of human sporadic brain arteriovenous malformations; a disorder characterized by direct connections between arteries and veins. However, whether this genetic abnormality alone is sufficient for lesion formation, as well as how active KRAS signaling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.