Article

Arteriovenous Malformations (AVMs): Molecular Pathogenesis, Clinical Features, and Emerging Therapeutic Strategies

2025-10-29

Abstract excerpt

Arteriovenous malformations (AVMs) are fast‑flow vascular malformations formed by direct artery–to-vein shunts without an intervening capillary bed, increasing the risk of hemorrhage and organ‑specific damage. A synthesis of recent advances shows that AVMs arise from interplay between germline susceptibility (ENG, ACVRL1, SMAD4, RASA1, EPHB4), somatic mosaicism (KRAS, MAP2K1, PIK3CA), perturbed signaling (TGF‑β/BM...

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Literature Corpus work: a35c869c-28a2-536f-a251-0663be66c916
DOI: 10.20944/preprints202510.2300.v1

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