Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activating KRAS Mutations Expressed in 3D Endothelial Spheroids Induce Blebbing Morphologies Associated with Amoeboid-like Migration.

Cells - 22 Dec 2025

McRobb Lucinda S, Lee Vivienne S, Stoodley Marcus A

Abstract excerpt

INTRODUCTION: A 3D endothelial spheroid model expressing mosaic gain-of-function KRAS mutations was established to further understand the molecular changes associated with sporadic brain arteriovenous malformations (AVMs). METHODS: Repellent 96-well U-bottom plates were seeded with human cerebral microvascular endothelial cells and resultant spheroids transduced with recombinant adeno-associated virus expressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Endothelial Cells
Share to KRAS gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Proto-Oncogene Proteins p21(ras)

Share to Spheroids, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 41511306
DOI: 10.3390/cells15010022
PMCID: PMC12784968

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating KRAS Mutations Expressed in 3D Endothelial Spheroids Induce Blebbing Morphologies Associated with Amoeboid-like Migration.PMID 41511306Read ↗

Development and characterization of a human model of arteriovenous malformation (AVM)-on-a-chipSemantic proximity Read ↗

Endothelial KRAS <sup>G12V</sup> signaling drives aberrant morphogenesis and establishes an AVM transcriptional identity in primary human endothelial cellsSemantic proximity Read ↗

Mutant KRAS in brain endothelial cells promotes vascular inflammation and impairs vascular integrity in brain arteriovenous malformation.Semantic proximity Read ↗

Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling.Semantic proximity Read ↗

CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice.Semantic proximity Read ↗

MEK signaling represents a viable therapeutic vulnerability of <i>KRAS</i> -driven somatic brain arteriovenous malformationsSemantic proximity Read ↗

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain.Semantic proximity Read ↗

Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice.Semantic proximity Read ↗

Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation.Semantic proximity Read ↗

Advances in the Study of KRAS in Brain Arteriovenous Malformation.Semantic proximity Read ↗

Dual MAPK/VEGF inhibition for KRAS-mutated brain arteriovenous malformations.Semantic proximity Read ↗

Endothelial k-RasV12 Expression Induces Capillary Deficiency Attributable to Marked Tube Network Expansion Coupled to Reduced Pericytes and Basement Membranes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.