Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain.

doi:10.1056/NEJMoa1709449

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Article

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain.

The New England journal of medicine - 18 Jan 2018

Nikolaev Sergey I, Vetiska Sandra, Bonilla Ximena, Boudreau Emilie, Jauhiainen Suvi, Rezai Jahromi Behnam, Khyzha Nadiya, DiStefano Peter V, Suutarinen Santeri, Kiehl Tim-Rasmus, Mendes Pereira Vitor, Herman Alexander M, Krings Timo, Andrade-Barazarte Hugo, Tung Takyee, Valiante Taufik, Zadeh Gelareh, Tymianski Mike, Rauramaa Tuomas, Ylä-Herttuala Seppo, Wythe Joshua D, Antonarakis Stylianos E, Frösen Juhana, Fish Jason E, Radovanovic Ivan

Abstract excerpt

BACKGROUND: Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagic stroke in young adults and children. The genetic cause of this rare focal disorder is unknown. METHODS: We analyzed tissue and blood samples from patients with arteriovenous malformations of the brain to detect somatic...

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PMID: 29298116
DOI: 10.1056/NEJMoa1709449
PMCID: PMC8161530

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KRAS

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