Article

Motor Skill Learning Modulates Striatal Extracellular Vesicles’ Content in a Mouse Model of Huntington’s Disease

2024-03-20

Abstract excerpt

<title>Abstract</title> <p>Huntington’s disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene (<italic>HTT</italic>). HD pathology mostly affects striatal medium-sized spiny neurons and results in an altered cortico-striatal function. Recent studies report that motor skill learning, and cortico-striatal stimulation attenuate the neuropathology in HD, resulting in an amelioration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 04c28fab-1723-54ea-8ed7-369c3eee3570
DOI: 10.21203/rs.3.rs-4017885/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Motor Skill Learning Modulates Striatal Extracellular Vesicles’ Content in a Mouse Model of Huntington’s DiseaseDOI 10.21203/rs.3.rs-4017885/v1Read

Early alterations of motor learning and corticostriatal network activity in a Huntington’s disease mouse modelSemantic proximity Read

Effect of chronic upregulation of endocannabinoid signaling <i>in vivo</i> with JZL184 on striatal synaptic plasticity and motor learning in YAC128 Huntington disease miceSemantic proximity Read

Synaptic RTP801 contributes to motor-learning dysfunction in Huntington’s diseaseSemantic proximity Read

Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s diseaseSemantic proximity Read

Extracellular vesicles improve GABAergic transmission in Huntington’s disease iPSC-derived neuronsSemantic proximity Read

SorCS2 Dynamically Interacts with TrkB and GluN2B to Control Neurotransmission and Huntington’s Disease ProgressionSemantic proximity Read

Developmental alterations of indirect-pathway medium spiny neurons in mouse models of Huntington’s diseaseSemantic proximity Read

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor functionSemantic proximity Read

Altered excitability and exocytosis in chromaffin cells from the R6/1 mouse model of Huntington's disease is linked to over-expression of mutated huntingtin.Semantic proximity Read

Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS.Semantic proximity Read

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.Semantic proximity Read

Identification of the key role of white matter alteration in the pathogenesis of Huntington’s DiseaseSemantic proximity Read