Article

SorCS2 Dynamically Interacts with TrkB and GluN2B to Control Neurotransmission and Huntington’s Disease Progression

2022-01-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor dysfunction and loss of medium spiny neurons (MSNs) in dorsal striatum. Brain-derived neurotrophic factor (BDNF) sustains functionality and integrity of MSNs, and thus reduced BDNF signaling is integral to the disease. Mutations in BDNF receptor SorCS2 were recentl...

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Literature Corpus work: e124a34f-e8e2-5cbb-b3e1-e46a94921a81
DOI: 10.21203/rs.3.rs-1086596/v2

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