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Article

Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS.

Nature communications - 7 Jun 2024

Mora Santiago, Stuckert Anna, von Huth Friis Rasmus, Pietersz Kimberly, Noes-Holt Gith, Montañana-Rosell Roser, Wang Haoyu, Sørensen Andreas Toft, Selvan Raghavendra, Verhaagen Joost, Allodi Ilary

Abstract excerpt

Loss of connectivity between spinal V1 inhibitory interneurons and motor neurons is found early in disease in the SOD1G93A mice. Such changes in premotor inputs can contribute to homeostatic imbalance of motor neurons. Here, we show that the Extended Synaptotagmin 1 (Esyt1) presynaptic organizer is downregulated in V1 interneurons. V1 restricted overexpression of Esyt1 rescues inhibitory synapses, increases motor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38849367
DOI: 10.1038/s41467-024-48925-7
PMCID: PMC11161600

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